SCHEMBL3631052

SCHEMBL3631052

CCCC[Si](C)(C)OCc1ccc(F)cc1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.41
AGXT P21549 2/20 0.41
HPGD P15428 1/20 0.41
PSMD14 O00487 1/20 0.38
HSP90AA1 P07900 1/20 0.38
MMP2 P08253 1/20 0.38
MC4R P32245 1/20 0.38
RAD52 P43351 1/20 0.38
FAAH O00519 1/20 0.38
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
KMT2A Q03164 1/20 0.35
MAOB P27338 3/20 0.35
HTR7 P34969 1/20 0.35
APP P05067 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1245957 0.83 ALDH1A1 (0.40) HPGDPSMD14HSP90AA1MMP2MC4R
SCHEMBL9549828 0.83 MAPT (0.46) HPGDALDH1A1GAAMAPTKMT2A
SCHEMBL9033202 0.83 IDO1 (0.41) IDO1HTTKMT2AMAOBAPP
SCHEMBL30190420 0.83 ESR1 (0.31) ALDH1A1
SCHEMBL7421540 0.79
SCHEMBL27805656 0.78 HDAC3 (0.34) HPGDALDH1A1
SCHEMBL5368865 0.77 MEN1 (0.30) MAPTKMT2A
SCHEMBL9549749 0.76 IDO1 (0.49) IDO1ALDH1A1MAPTMAOB
SCHEMBL15737095 0.76 TAAR1 (0.39) HPGDALDH1A1GAAMAPTHTT
SCHEMBL28293808 0.76 PSMD14 (0.39) IDO1AGXTHPGDPSMD14HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101137660-B Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives as antidiabetic compounds HOFFMANN LA ROCHE 2011-06-15 CN disclosed
CN-101253171-B Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives HOFFMANN LA ROCHE 2011-06-15 CN disclosed
CN-101679260-A 4,4-disubstituted piperidine derivatives HOFFMANN LA ROCHE 2010-03-24 CN disclosed
CN-101679368-A Aryl azoles, aryl diazole and benzimidizole derivatives HOFFMANN LA ROCHE 2010-03-24 CN disclosed
EP-2152710-A2 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES F. Hoffmann-Roche AG (CH) 2010-02-17 EP disclosed
CN-101646665-A 1-(1-benzyl piepridine-4-yl) benzoglyoxaline-5-carboxylic acid derivative that is used for the treatment of diabetes HOFFMANN LA ROCHE CH 2010-02-10 CN disclosed
EP-2142528-A1 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS F. Hoffmann-Roche AG (CH) 2010-01-13 EP disclosed
CN-101511817-A Pyridine-and quinoline-pyrimidine derivatives HOFFMANN LA ROCHE (CH) 2009-08-19 CN disclosed
CN-101479257-A Pyrimidine and quinazoline derivatives HOFFMANN LA ROCHE (CH) 2009-07-08 CN disclosed
EP-2066658-A1 PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2009-06-10 EP disclosed
EP-2054385-A2 PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES F. Hoffmann-Roche AG (CH) 2009-05-06 EP disclosed
CN-101405284-A Pyrimidine, quinazoline, pteridine and derivatives HOFFMANN LA ROCHE (CH) 2009-04-08 CN disclosed
WO-2008145524-A2 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2008-12-04 WO disclosed
WO-2008122510-A1 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS F. HOFFMANN-LA ROCHE AG (CH) 2008-10-16 WO disclosed
CN-101253171-A Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives HOFFMANN LA ROCHE (CH) 2008-08-27 CN disclosed
CN-101189226-A Piperidin-4-yl-amide derivatives and their use as SST receptor subtype 5 antagonists HOFFMANN LA ROCHE (CH) 2008-05-28 CN disclosed
WO-2008031735-A1 PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2008-03-20 WO disclosed
CN-101137660-A Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives as antidiabetic compounds HOFFMANN LA ROCHE (CH) 2008-03-05 CN disclosed
WO-2008019967-A2 PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2008-02-21 WO disclosed