Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | AOC1 | P19801 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17469029 | 0.81 | TRPM5 (0.39) | TRPM5 | |
| SCHEMBL5439074 | 0.74 | CYP3A4 (0.39) | TRPM5 | |
| SCHEMBL910839 | 0.69 | KDM4E (0.39) | TRPM5 | |
| SCHEMBL8071753 | 0.69 | TRPM5 (0.39) | TRPM5 | |
| SCHEMBL113854 | 0.68 | CYP2A6 (0.46) | PNMTDPP4 | |
| SCHEMBL3631061 | 0.67 | PLK4 (0.47) | TRPM5 | |
| SCHEMBL29696556 | 0.67 | PLK4 (0.47) | TRPM5 | |
| Hydrochloric Acid SCHEMBL2525624 | 0.67 | DAO (0.44) | PNMTDPP4 | |
| SCHEMBL11382202 | 0.65 | ALDH1A1 (0.46) | TRPM5 | |
| SCHEMBL30129737 | 0.65 | ALDH1A1 (0.46) | TRPM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674810-B2 | 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase | ROCHE PALO ALTO LLC (US) | 2010-03-09 | — | — | US | disclosed |
| US-20060252785-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252785-A1 | Heterocyclic antiviral compounds | EIF2AK2, HAVCR2, POLR2E | TRPM5 3909/4885PNMT 1559/4885DPP4 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.