Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910839 | 0.74 | KDM4E (0.39) | TRPM5RAB9AKDM4ELMNAMAPT | |
| SCHEMBL5439074 | 0.74 | CYP3A4 (0.39) | TRPM5NPC1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL8057979 | 0.74 | TRPM5 (0.39) | TRPM5HDAC4 | |
| SCHEMBL659713 | 0.71 | SLC22A12 (0.31) | TRPM5 | |
| SCHEMBL11382202 | 0.70 | ALDH1A1 (0.46) | TRPM5NPC1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL30129737 | 0.70 | ALDH1A1 (0.46) | TRPM5NPC1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL12603990 | 0.69 | CA2 (0.39) | TRPM5MAPTTDP1ALDH1A1 | |
| SCHEMBL17469029 | 0.69 | TRPM5 (0.39) | TRPM5SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL13913279 | 0.69 | GABRA1 (0.39) | TRPM5LMNAHPGD | |
| SCHEMBL29696556 | 0.67 | PLK4 (0.47) | TRPM5KDM4EMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454621-B1 | Nematicide agents | NOVARTIS AG (CH) | 2000-07-12 | — | — | EP | disclosed |
| US-5447945-A | Controlling or preventing nematocidal attack on cultivated plants with nitro- or halo-substituted benzisothiazoles | CIBA-GEIGY CORPORATION (US) | 1995-09-05 | — | — | US | disclosed |
| US-5169951-A | PROCESS FOR PREPARING NEMATICIDAL COMPOSITIONS | CIBA-GEIGY CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0454621-A2 | Nematicide agents | CIBA-GEIGY AG (CH) | 1991-10-30 | — | — | EP | disclosed |