Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365085 | 0.91 | NR1H2 (0.41) | NR1H2MAP4K4TGFBR1MAPK14ATR | |
| SCHEMBL364292 | 0.91 | NR1H2 (0.34) | NR1H2GRM5GPBAR1NR1H3 | |
| SCHEMBL363020 | 0.88 | ATR (0.35) | NR1H2MAP4K4TGFBR1MAPK14GRM5 | |
| SCHEMBL363922 | 0.88 | NR1H2 (0.41) | NR1H2MAP4K4NR1H3PTGS2SYK | |
| SCHEMBL363868 | 0.87 | CCR9 (0.34) | MAPK14GRM5ATRPTGS2PTGS1 | |
| SCHEMBL365288 | 0.87 | CCR9 (0.34) | MAPK14GRM5ATRPTGS2PTGS1 | |
| SCHEMBL364180 | 0.86 | GPBAR1 (0.35) | GPBAR1 | |
| SCHEMBL364263 | 0.85 | GPBAR1 (0.31) | GPBAR1 | |
| SCHEMBL363805 | 0.85 | GPBAR1 (0.31) | GPBAR1 | |
| SCHEMBL364539 | 0.84 | POLB (0.32) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |