Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.34 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.34 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.34 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1396181 | 0.83 | QPCT (0.47) | APLNRHIF1AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2886185 | 0.83 | RAB9A (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL21067103 | 0.82 | AGBL2 (0.40) | APLNRAGBL2NPC1RAB9AALDH1A1 | |
| SCHEMBL3633272 | 0.79 | DAO (0.42) | NPC1RAB9APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL2846514 | 0.79 | HIF1A (0.51) | NPC1RAB9AHIF1ASMN1; SMN2 | |
| SCHEMBL30941107 | 0.71 | NPC1 (0.62) | NPC1RAB9APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL3934379 | 0.70 | APLNR (0.50) | APLNR | |
| SCHEMBL1396182 | 0.69 | APLNR (0.46) | APLNRAGBL2NPC1RAB9A | |
| SCHEMBL2947631 | 0.68 | AGBL2 (0.36) | AGBL2NPC1RAB9AHIF1AALDH1A1 | |
| SCHEMBL6168564 | 0.68 | KMT2A (0.41) | HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152702-A1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2009013545-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | WO | disclosed |
| WO-2008135786-A1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |