Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257990 | 0.82 | P2RX7 (0.40) | ASAH1TRPV1SMN1; SMN2NAAA | |
| SCHEMBL2840152 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDLMNA | |
| SCHEMBL31036071 | 0.80 | MEN1 (0.55) | KMT2ATRPV1SMN1; SMN2 | |
| SCHEMBL2846951 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2HPGDNAAALMNA | |
| SCHEMBL18794901 | 0.76 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL2846544 | 0.75 | CYP1A2 (0.48) | ASAH1 | |
| SCHEMBL2399053 | 0.75 | MAPT (0.52) | SMN1; SMN2LMNATSHR | |
| SCHEMBL17057294 | 0.74 | SMN1; SMN2 (0.42) | KMT2ASMN1; SMN2HPGDLMNATSHR | |
| SCHEMBL2843465 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2HPGDLMNA | |
| SCHEMBL2841416 | 0.74 | HTR1A (0.49) | ASAH1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539159-A1 | SULPHONYLPIPERIDINE DERIVATIVES CONTAINING AN ARYL OR HETEROARYL GROUP FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | Astrazeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| EP-1534281-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | Astrazeneca AB (SE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004006926-A1 | SULPHONYLPIPERIDINE DERIVATIVES CONTAINING AN ARYL OR HETEROARYL GROUP FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004006925-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | disclosed |