Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502383 | 0.90 | HPGD (0.53) | CHEK1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1502335 | 0.84 | HTR1A (0.47) | CHEK1HTR1ASLC6A4HTR2BADRB2 | |
| SCHEMBL1501979 | 0.84 | HTR1A (0.60) | CHEK1HTR1ASLC6A4HTR2BADRB2 | |
| SCHEMBL1502088 | 0.77 | LMNA (0.52) | CHEK1HTR1ASLC6A4HTR2BHTR2A | |
| SCHEMBL1502407 | 0.74 | HTR4 (0.48) | CHEK1HTR1ASLC6A4HTR2BMEN1 | |
| SCHEMBL1502385 | 0.73 | KDM4E (0.52) | CHEK1HTR1AALDH1A1KDM4EMEN1 | |
| SCHEMBL1501969 | 0.73 | HTR4 (0.66) | HTR2BHTR2AALDH1A1KDM4ELMNA | |
| SCHEMBL13162864 | 0.73 | CHEK1 (0.56) | CHEK1SLC6A4SLC6A2ALDH1A1KDM4E | |
| SCHEMBL14029259 | 0.73 | KMT2A (0.67) | HTR1ASLC6A4HTR2BALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9021789 | 0.73 | HTR4 (0.65) | KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148867-B1 | DEUTERATED MORPHOLINYL COMPOUNDS | CONCERT PHARMACEUTICALS INC (US) | 2014-09-10 | — | — | EP | disclosed |
| EP-2148867-A1 | DEUTERATED MORPHOLINYL COMPOUNDS | Concert Pharmaceuticals Inc. (US) | 2010-02-03 | — | — | EP | disclosed |
| US-7528131-B2 | Substituted morpholinyl compounds | CONCERT PHARMACEUTICALS INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-7528131-B2 | Substituted morpholinyl compounds | CONCERT PHARMACEUTICALS INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-7528131-B2 | Substituted morpholinyl compounds | CONCERT PHARMACEUTICALS INC. (US) | 2009-05-05 | — | — | US | disclosed |
| WO-2008131259-A1 | DEUTERATED MORPHOLINYL COMPOUNDS | CONCERT PHARMACEUTICALS INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008131259-A1 | DEUTERATED MORPHOLINYL COMPOUNDS | CONCERT PHARMACEUTICALS INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080261983-A1 | Substituted morpholinyl compounds | CONCERT PHARMACEUTICALS INC. (US) | 2008-10-23 | — | — | US | disclosed |
| US-20080261983-A1 | Substituted morpholinyl compounds | CONCERT PHARMACEUTICALS INC. (US) | 2008-10-23 | — | — | US | disclosed |
| US-20080261983-A1 | Substituted morpholinyl compounds | CONCERT PHARMACEUTICALS INC. (US) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261983-A1 | Substituted morpholinyl compounds | HTR4, SLC6A4, HTR3B | CHEK1 1336/4885HTR1A 8/4885SLC6A4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.