Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.33 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967098 | 0.84 | IMPDH2 (0.44) | PDE7APDE7BPDE4DALDH1A1GAA | |
| SCHEMBL3663746 | 0.77 | ALDH1A1 (0.41) | ALDH1A1GAAKDM4ELMNAPOLB | |
| SCHEMBL3733422 | 0.75 | PDE5A (0.31) | CCNT1CCNA2CDK2CDK9CCNA1 | |
| SCHEMBL3660492 | 0.75 | CYP3A4 (0.43) | ALDH1A1GAAKDM4ELMNAPOLB | |
| SCHEMBL3411515 | 0.75 | KIT (0.37) | PDE7AALDH1A1GAAKDM4ELMNA | |
| SCHEMBL3633331 | 0.71 | KDM4E (0.41) | ALDH1A1KDM4ELMNAMCL1MDM4 | |
| SCHEMBL3637473 | 0.69 | IMPDH2 (0.43) | PDE7APDE7BPDE4DALDH1A1GAA | |
| SCHEMBL1226779 | 0.69 | PDE7A (0.44) | PDE7APDE7BPDE4DALDH1A1GAA | |
| SCHEMBL6747997 | 0.68 | IMPDH2 (0.42) | TLR8MCHR1ALDH1A1GAAIMPDH2 | |
| SCHEMBL8145073 | 0.68 | ALDH1A1 (0.48) | TLR8MCHR1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |