Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660492 | 0.83 | CYP3A4 (0.43) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL3411515 | 0.83 | KIT (0.37) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL1967098 | 0.81 | IMPDH2 (0.44) | ALDH1A1KDM4EMAPTGAALMNA | |
| SCHEMBL3633331 | 0.80 | KDM4E (0.41) | ALDH1A1KDM4EMAPTHPGDHSD17B10 | |
| SCHEMBL3634102 | 0.77 | CCNT1 (0.36) | ALDH1A1KDM4EGAAPOLBLMNA | |
| SCHEMBL24360032 | 0.74 | DCUN1D1 (0.50) | ALDH1A1KDM4EGAAHPGDNPC1 | |
| SCHEMBL3635215 | 0.74 | NPC1 (0.44) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL15651168 | 0.74 | NISCH (0.46) | ALDH1A1PDE10AKDM4EMAPTGAA | |
| SCHEMBL6802067 | 0.72 | HPGD (0.50) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL16280579 | 0.72 | ALDH1A1 (0.65) | ALDH1A1PDE10AKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |