Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445492 | 0.84 | DCUN1D1 (0.32) | — | |
| SCHEMBL3634102 | 0.75 | CCNT1 (0.36) | PDE5ACCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3731693 | 0.72 | HSP90AB1 (0.32) | — | |
| SCHEMBL25438757 | 0.69 | IRAK4 (0.32) | — | |
| SCHEMBL3728883 | 0.69 | DCUN1D1 (0.31) | — | |
| SCHEMBL7701984 | 0.68 | ALDH1A1 (0.39) | — | |
| SCHEMBL676940 | 0.68 | ALDH1A1 (0.35) | — | |
| SCHEMBL3735342 | 0.67 | GAA (0.33) | — | |
| SCHEMBL3665728 | 0.65 | GAA (0.33) | — | |
| SCHEMBL1476996 | 0.65 | IRAK4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |