Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | DVL1 | O14640 | 1/20 | 0.37 |
| ▸ | DVL3 | Q92997 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634689 | 0.86 | MAPK8 (0.42) | MAPK8KMT2AALDH1A1MAPK9MAPK10 | |
| SCHEMBL3631272 | 0.85 | MAPK8 (0.44) | MAPK8KMT2AALDH1A1KDM4EMAPK9 | |
| SCHEMBL3634381 | 0.85 | MAPK8 (0.53) | MAPK8HPGDKMT2ASMN1; SMN2MAPK9 | |
| SCHEMBL3940003 | 0.84 | MAPK8 (0.52) | MAPK8MAPK9MAPK10NPC1RAB9A | |
| SCHEMBL3939176 | 0.82 | IKBKB (0.40) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3635595 | 0.79 | MAPK8 (0.40) | MAPK8HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL3634026 | 0.79 | MAPK8 (0.44) | MAPK8KMT2AMAPK9MEN1MCL1 | |
| SCHEMBL3945638 | 0.78 | MAPK8 (0.39) | MAPK8KMT2AALDH1A1MAPK9MAPK10 | |
| SCHEMBL3636491 | 0.78 | TP53 (0.40) | MAPK8HPGDALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14604210 | 0.78 | MAPK8 (0.51) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |