Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940003 | 0.86 | MAPK8 (0.52) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3634381 | 0.84 | MAPK8 (0.53) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3634689 | 0.84 | MAPK8 (0.42) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3631272 | 0.83 | MAPK8 (0.44) | MAPK8MAPK9MAPK10 | |
| SCHEMBL3938366 | 0.82 | MAPK8 (0.52) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14604210 | 0.79 | MAPK8 (0.51) | MAPK8 | |
| SCHEMBL14604229 | 0.79 | MAPK8 (0.49) | MAPK8 | |
| SCHEMBL14604008 | 0.79 | MAPK8 (0.48) | MAPK8 | |
| SCHEMBL14604103 | 0.78 | MAPK8 (0.51) | MAPK8 | |
| SCHEMBL3635595 | 0.77 | MAPK8 (0.40) | MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |