Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320692 | 0.81 | SIGMAR1 (0.44) | SIGMAR1OPRM1HTR1A | |
| SCHEMBL3663846 | 0.71 | SIGMAR1 (0.47) | SIGMAR1 | |
| SCHEMBL14645859 | 0.71 | SIGMAR1 (0.68) | SIGMAR1 | |
| SCHEMBL10998697 | 0.59 | LMNA (0.49) | SIGMAR1OPRM1HTR1ASLC6A4 | |
| SCHEMBL4169559 | 0.59 | SIGMAR1 (0.67) | SIGMAR1 | |
| SCHEMBL11789571 | 0.58 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL1309373 | 0.58 | HRH2 (0.52) | SIGMAR1 | |
| Bromide SCHEMBL4174825 | 0.58 | SIGMAR1 (0.65) | SIGMAR1 | |
| SCHEMBL29748826 | 0.58 | SIGMAR1 (0.52) | SIGMAR1 | |
| SCHEMBL28283654 | 0.58 | CHRNB2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155748-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008144268-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-11-27 | — | — | WO | disclosed |