Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL11538523 | 0.88 | ALDH1A1 (0.65) | ALDH1A1HSD17B10SOAT1TDP1LMNA | |
| SCHEMBL3634892 | 0.85 | HSD17B10 (0.69) | ALDH1A1HSD17B10SOAT1TDP1USP2 | |
| Propylene Glycol SCHEMBL56047 | 0.83 | HSD17B10 (0.64) | ALDH1A1HSD17B10TDP1USP2LMNA | |
| Propylene Glycol SCHEMBL10765776 | 0.83 | HSD17B10 (0.64) | ALDH1A1HSD17B10TDP1USP2LMNA | |
| Propylene Glycol SCHEMBL122754 | 0.82 | HSD17B10 (0.52) | ALDH1A1HSD17B10TDP1USP2MAPT | |
| Propylene Glycol SCHEMBL10613711 | 0.81 | HSD17B10 (0.61) | ALDH1A1HSD17B10TDP1USP2LMNA | |
| Propylene Glycol SCHEMBL28092305 | 0.81 | HSD17B10 (0.61) | ALDH1A1HSD17B10TDP1USP2LMNA | |
| Propylene Glycol SCHEMBL445698 | 0.80 | HSD17B10 (0.50) | HSD17B10TDP1USP2MAPTMEN1 | |
| SCHEMBL10978252 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HSD17B10SOAT1LMNACYP4F2 | |
| Propylene Glycol SCHEMBL2748505 | 0.79 | HSD17B10 (0.58) | ALDH1A1HSD17B10TDP1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164648-A1 | LOW K DIELECTRIC | Sba Materials, Inc. (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008156680-A1 | LOW K DIELECTRIC | SBA MATERIALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |