Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.31 |
| ▸ | GABRD | O14764 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.31 |
| ▸ | GABRE | P78334 | 2/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.31 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.31 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.31 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL736567 | 1.00 | ALDH1A1 (0.32) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| Bicarbonate SCHEMBL6829816 | 0.89 | ALDH1A1 (0.38) | ALDH1A1LMNAHSD17B10FFAR3 | |
| Bicarbonate SCHEMBL700909 | 0.81 | TSHR (0.42) | ALDH1A1TSHRFFAR3 | |
| Bicarbonate SCHEMBL95011 | 0.81 | TSHR (0.42) | ALDH1A1TSHRFFAR3 | |
| Bicarbonate SCHEMBL5385074 | 0.78 | TSHR (0.40) | ALDH1A1TSHRFFAR3 | |
| SCHEMBL173031 | 0.78 | — | — | |
| Bicarbonate SCHEMBL4239205 | 0.76 | TSHR (0.35) | TSHR | |
| Benzene SCHEMBL28129217 | 0.75 | TSHR (0.38) | ALDH1A1TSHR | |
| Bicarbonate SCHEMBL10901198 | 0.74 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10TSHRFFAR3 | |
| Bicarbonate SCHEMBL9343891 | 0.70 | LMNA (0.52) | ALDH1A1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2160653-A1 | TONER, AND METHOD FOR PRODUCING THE SAME | Ricoh Company, Ltd. (JP) | 2010-03-10 | — | — | EP | disclosed |
| WO-2009008251-A1 | TONER, AND METHOD FOR PRODUCING THE SAME | RICOH COMPANY, LTD. (JP) | 2009-01-15 | — | — | WO | disclosed |