Aspartame

Aspartame

SCHEMBL3636

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.64
THRB P10828 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64
HSD17B10 Q99714 1/20 0.64
OPRK1 P41145 1/20 0.58
ATM Q13315 2/20 0.58
POLB P06746 1/20 0.55
BIRC2 Q13490 1/20 0.54
LMNA P02545 1/20 0.53
GLA P06280 1/20 0.53
TSHR P16473 1/20 0.53
ANPEP P15144 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aspartame SCHEMBL19283498 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL10625481 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL28591 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL900809 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL216238 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL3637 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL10635593 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL11085391 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL8091203 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL8761655 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 176375 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6432470-B1 None US claimed
US-20260144747-A1 SYRUP PREPARATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2026-05-28 US claimed
US-20260144282-A1 CRYSTALLINE COMPLEX, METHOD FOR PRODUCING THEREOF, AND COMPOSITION KANEKA CORPORATION (JP) 2026-05-28 US claimed
EP-4223352-B1 DRUG-COATED BALLOON CATHETERS FOR BODY LUMENS UROTRONIC INC (US) 2026-05-27 EP claimed
CN-122074582-A Ice cream capable of reducing shrinkage collapse and preparation method thereof 2026-05-26 CN claimed
CN-122075667-A BPC-157 sodium salt oral dissolved film preparation for treating acute alcoholism and preparation method thereof 2026-05-26 CN claimed
CN-122075589-A Preparation method of pelvic inflammation eliminating oral liquid 2026-05-26 CN claimed
CN-122075449-A Soxotalol hydrochloride film agent for oral instant administration and preparation method thereof 2026-05-26 CN claimed
CN-122074696-A Buccal product and preparation method thereof 2026-05-26 CN claimed
CN-122074633-A Flavour composition, aqueous food composition containing said flavour composition, preparation and use thereof 2026-05-26 CN claimed
US-4001456-A LOW CALORIE SWEETENING COMPOSITION AND METHOD FOR MAKING SAME GENERAL FOODS CORPORATION (US) 1977-01-04 US claimed
US-3982023-A L-ASPARTYL-L-PHENYLALANINE, ARTIFICIAL SWEETENER GENERAL FOODS CORPORATION (US) 1976-09-21 US claimed
US-3971857-A DIPEPTIDE, POLYGLUCOSE GENERAL FOODS CORPORATION (US) 1976-07-27 US claimed
US-3965273-A CALCIUM CARBONATE IN CARBOHYDRATE GENERAL FOODS CORPORATION (US) 1976-06-22 US claimed
US-3943258-A L-ASPARTYL-L-PHENYLALANINE METHYL ESTER GENERAL FOODS CORPORATION (US) 1976-03-09 US claimed
US-3939289-A Dry carbonation source for a beverage concentrate and method of preparing the same GENERAL FOODS CORPORATION (US) 1976-02-17 US claimed
US-3939261-A DIPEPTIDE SWEETENER, ACID ANHYDRIDE COLGATE-PALMOLIVE COMPANY (US) 1976-02-17 US claimed
US-3934048-A Multifunctional sweetening composition GENERAL FOODS CORPORATION (US) 1976-01-20 US claimed
US-3934047-A Taste modifier for artificial sweeteners GENERAL FOODS CORPORATION (US) 1976-01-20 US claimed
US-3933781-A Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters MONSANTO COMPANY (US) 1976-01-20 US claimed