Aspartame

Aspartame

SCHEMBL900809

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O.COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.64
THRB P10828 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64
HSD17B10 Q99714 1/20 0.64
OPRK1 P41145 1/20 0.58
ATM Q13315 2/20 0.58
POLB P06746 1/20 0.55
BIRC2 Q13490 1/20 0.54
LMNA P02545 1/20 0.53
GLA P06280 1/20 0.53
TSHR P16473 1/20 0.53
ANPEP P15144 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aspartame SCHEMBL19283498 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL10625481 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL28591 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL216238 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL3637 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL10635593 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL11085391 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL8091203 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL8761655 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL3636 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060083837-A1 Aspartame blend MONFRE JOHN G 2006-04-20 US claimed
US-6294686-B1 Aspartame crystals and process for the preparation thereof YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2001-09-25 US claimed
EP-1025117-A1 NOVEL ASPARTAME CRYSTALS AND PROCESS FOR THE PREPARATION THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2000-08-09 EP claimed
WO-1999021876-A1 NOVEL ASPARTAME CRYSTALS AND PROCESS FOR THE PREPARATION THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1999-05-06 WO claimed
EP-3419433-A1 ENCAPSULATED SWEETENERS AND METHOD FOR PRODUCING SAME Wacker Chemie AG (DE) 2019-01-02 EP disclosed
EP-2621462-A1 ORAL CARE COMPOSITIONS WITH IMPROVED FLAVOR The Procter and Gamble Company (US) 2013-08-07 EP disclosed
WO-2012044728-A1 ORAL CARE COMPOSITIONS WITH IMPROVED FLAVOR THE PROCTER & GAMBLE COMPANY (US) 2012-04-05 WO disclosed
EP-2320745-A1 SWEETENER, METHODS OF PREPARING SWEETENER AND APPLICATIONS THEREOF Cargill, Incorporated (US) 2011-05-18 EP disclosed
WO-2009137838-A1 SWEETENER, METHODS OF PREPARING SWEETENER AND APPLICATIONS THEREOF CARGILL, INCORPORATED (US) 2009-11-12 WO disclosed
US-7208186-B2 Chewing gum formulation and method of making the same SPI PHARMA, INC. (US) 2007-04-24 US disclosed
WO-2007038524-A2 COCRYSTALLIZATION METHODS SSCI, INC. (US) 2007-04-05 WO disclosed
CN-1845679-A Chewable antiplaque confectionery dental composition COLGATE PALMOLIVE CO (US) 2006-10-11 CN disclosed
EP-1025117-A1 NOVEL ASPARTAME CRYSTALS AND PROCESS FOR THE PREPARATION THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2000-08-09 EP disclosed
WO-2000036930-A1 GELATIN REPLACEMENT COMPOSITION CP KELCO U.S., INC. (US) 2000-06-29 WO disclosed
WO-1999021876-A1 NOVEL ASPARTAME CRYSTALS AND PROCESS FOR THE PREPARATION THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1999-05-06 WO disclosed
US-5721229-A DRY, SOLID MIXTURE WITH HYDROXYPOLYCARBOXYLIC ACID VETERINARY PHARMACY CORPORATION (US) 1998-02-24 US disclosed
WO-1996009292-A1 1,5-DIPHENYL-3-(N-HYDROXYCARBAMOYLOXYALKYL)PYRAZOLES ORTHO PHARMACEUTICAL CORPORATION (US) 1996-03-28 WO disclosed
US-5387602-A Antiinflammatory agents ORTHO PHARMACEUTICAL CORPORATION (US) 1995-02-07 US disclosed
US-5298521-A Anti-inflammatory agent ORTHO PHARMACEUTICAL CORPORATION (US) 1994-03-29 US disclosed
WO-1993022939-A1 IMPROVED HIGH INTENSITY SWEETENER INGREDIENT WM. WRIGLEY, JR. COMPANY (US) 1993-11-25 WO disclosed