Aspartame

Aspartame

SCHEMBL3637

COC(=O)C(Cc1ccccc1)NC(=O)C(N)CC(=O)O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.64
THRB P10828 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64
HSD17B10 Q99714 1/20 0.64
OPRK1 P41145 1/20 0.58
ATM Q13315 2/20 0.58
POLB P06746 1/20 0.55
BIRC2 Q13490 1/20 0.54
LMNA P02545 1/20 0.53
GLA P06280 1/20 0.53
TSHR P16473 1/20 0.53
ANPEP P15144 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aspartame SCHEMBL19283498 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL10625481 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL28591 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL900809 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL216238 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL10635593 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL11085391 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL8091203 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL8761655 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10
Aspartame SCHEMBL3636 1.00 ALDH1A1 (0.64) ALDH1A1THRBCYP2C9CYP2C19HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 173231 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144747-A1 SYRUP PREPARATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2026-05-28 US claimed
US-20260144282-A1 CRYSTALLINE COMPLEX, METHOD FOR PRODUCING THEREOF, AND COMPOSITION KANEKA CORPORATION (JP) 2026-05-28 US claimed
EP-4223352-B1 DRUG-COATED BALLOON CATHETERS FOR BODY LUMENS UROTRONIC INC (US) 2026-05-27 EP claimed
CN-122074582-A Ice cream capable of reducing shrinkage collapse and preparation method thereof 2026-05-26 CN claimed
CN-122075589-A Preparation method of pelvic inflammation eliminating oral liquid 2026-05-26 CN claimed
CN-122074696-A Buccal product and preparation method thereof 2026-05-26 CN claimed
CN-122075449-A Soxotalol hydrochloride film agent for oral instant administration and preparation method thereof 2026-05-26 CN claimed
CN-122075667-A BPC-157 sodium salt oral dissolved film preparation for treating acute alcoholism and preparation method thereof 2026-05-26 CN claimed
CN-122074633-A Flavour composition, aqueous food composition containing said flavour composition, preparation and use thereof 2026-05-26 CN claimed
CN-122070909-A Ambroxol anhydrous swallow granule and preparation method thereof 华益泰康药业股份有限公司 2026-05-22 CN claimed
US-4352824-A DELAYED BUT PROLONGED FLAVOR NABISCO BRANDS, INC. (US) 1982-10-05 US claimed
US-4338350-A INSTANT FOODS AMSTAR CORPORATION (US) 1982-07-06 US claimed
EP-0036258-A2 Process for producing aspartame CETUS CORPORATION (US) 1981-09-23 EP claimed
US-4277464-A ANTICARIES AGENTS GENERAL FOODS CORPORATION (US) 1981-07-07 US claimed
EP-0027024-A2 Aspartame-sweetened chewing gum and method of producing same WARNER-LAMBERT COMPANY (US) 1981-04-15 EP claimed
US-4248894-A SACCHARIN OR L-ASPARTYL-L-PHENYLALANING METHYL ESTER LIFE SAVERS, INC. (US) 1981-02-03 US claimed
US-4238475-A HYDROCOLLOID COATINGS OF THERAPEUTIC PARTICLES DISPERSED IN THE GUM LIFE SAVERS INC. (US) 1980-12-09 US claimed
US-4217368-A Long-lasting chewing gum and method LIFE SAVERS, INC. (US) 1980-08-12 US claimed
US-4208431-A SWEETENER, SOFTENER LIFE SAVERS, INC. (US) 1980-06-17 US claimed
US-4088649-A ACIDIC CYCLIZATION OF ASPARTAME IN LOWER ALKANOL, AMMONIATION; CHEESE FLAVOR FIRMENICH S.A. (CH) 1978-05-09 US claimed