Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.57 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | F3 | P13726 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10719176 | 0.98 | MAPT (0.59) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL2128854 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL28370740 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL7629150 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL2832028 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL2128849 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL29371090 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL84057 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL18788602 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 | |
| Chloroform SCHEMBL1827856 | 0.82 | CYP1A2 (0.79) | MAPTHDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367684-B2 | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2013-02-05 | — | — | US | disclosed |
| EP-2170861-B1 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INT (US) | 2012-08-29 | — | — | EP | disclosed |
| EP-2170861-A2 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS | Valeant Pharmaceuticals International (US) | 2010-04-07 | — | — | EP | disclosed |
| US-20080318979-A1 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2008-12-25 | — | — | US | disclosed |
| WO-2008157404-A2 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318979-A1 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS | KCNH2, KCNA6, KCNA1 | MAPT 3868/4885HDAC3 441/4885HDAC4 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.