Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636766 | 0.85 | NPC1 (0.31) | NPC1 | |
| SCHEMBL1314051 | 0.85 | NPC1 (0.35) | NPC1MAPTDGAT1 | |
| SCHEMBL2990695 | 0.76 | F11 (0.39) | NPC1MAPTDGAT1 | |
| SCHEMBL67719 | 0.75 | DGAT1 (0.35) | NPC1DGAT1 | |
| SCHEMBL5213310 | 0.74 | DGAT1 (0.37) | NPC1DGAT1 | |
| SCHEMBL1316068 | 0.74 | NPC1 (0.35) | NPC1MAPTDGAT1 | |
| SCHEMBL3637817 | 0.73 | DGAT1 (0.33) | NPC1DGAT1 | |
| SCHEMBL1313801 | 0.73 | ALDH1A1 (0.44) | NPC1MAPT | |
| SCHEMBL616134 | 0.72 | DGAT1 (0.32) | NPC1DGAT1 | |
| SCHEMBL23123528 | 0.72 | DGAT1 (0.34) | NPC1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |