Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.50 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.50 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.50 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637823 | 0.79 | ALOX5AP (0.43) | KDM4EALDH1A1TDP1 | |
| SCHEMBL4072935 | 0.70 | NPC1 (0.44) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL617991 | 0.69 | NPC1 (1.00) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL18075701 | 0.68 | KDM4E (1.00) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL6965384 | 0.68 | RAB9A (0.46) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL22930416 | 0.67 | MAPT (1.00) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL26802185 | 0.67 | RAB9A (0.68) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL11055398 | 0.67 | MAPT (0.56) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL10347621 | 0.66 | MAPT (0.55) | NPC1KDM4EMAPTRAB9AALDH1A1 | |
| SCHEMBL3731059 | 0.66 | NPC1 (0.55) | NPC1KDM4EMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |