Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637649 | 0.79 | NPC1 (0.53) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL28693493 | 0.77 | NR1H2 (0.41) | ALDH1A1KDM4ECHEK1AURKACSNK1A1 | |
| SCHEMBL8045718 | 0.73 | CCR2 (0.47) | ALOX5APALDH1A1KDM4ECHEK1AURKA | |
| SCHEMBL15544534 | 0.71 | KDM4E (0.46) | ALDH1A1KDM4ECHEK1AURKACSNK1A1 | |
| SCHEMBL482647 | 0.71 | ALDH1A1 (0.41) | ALOX5APALDH1A1KDM4ECHEK1AURKA | |
| SCHEMBL6420483 | 0.70 | KDM4E (0.45) | KDM4ECHEK1AURKACSNK1A1LIMK1 | |
| SCHEMBL28681187 | 0.69 | GABRG2 (0.41) | ALDH1A1KDM4ECHEK1AURKACSNK1A1 | |
| SCHEMBL335868 | 0.67 | NPC1 (0.47) | ALDH1A1KDM4ECHEK1AURKACSNK1A1 | |
| SCHEMBL14000394 | 0.65 | ALDH1A1 (0.70) | ALDH1A1KDM4EHTT | |
| SCHEMBL2364886 | 0.65 | PKM (0.44) | KDM4EDYRK1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |