Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.46 |
| ▸ | NPC1 | O15118 | 11/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182307 | 0.77 | MCL1 (0.56) | MAPTKDM4ESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11266333 | 0.73 | SMN1; SMN2 (0.51) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL6972868 | 0.72 | HRAS (0.54) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6976271 | 0.71 | HRAS (0.54) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL11248902 | 0.70 | MEN1 (0.46) | RAB9ANPC1RECQLLMNAALDH1A1 | |
| SCHEMBL6970444 | 0.69 | EGFR (0.53) | RAB9ANPC1SMN1; SMN2POLBCYP2C19 | |
| SCHEMBL6970911 | 0.69 | RAB9A (0.44) | RAB9ANPC1MAPTSMN1; SMN2POLB | |
| SCHEMBL6964928 | 0.69 | PIN1 (0.43) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2364886 | 0.68 | PKM (0.44) | MAPTKDM4ECYP1A2CYP2C19LMNA | |
| SCHEMBL3637649 | 0.68 | NPC1 (0.53) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937070-B1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA ITALIA SPA (IT) | 2003-12-03 | — | — | EP | disclosed |
| US-6153642-A | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-28 | — | — | US | disclosed |
| EP-0937070-A1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998021202-A1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-05-22 | — | — | WO | disclosed |