Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638560 | 0.92 | MAPK1 (0.50) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL21774760 | 0.85 | MAPT (0.45) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL4584445 | 0.84 | MAPT (0.55) | MAPTHTTKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL22609596 | 0.83 | MAPT (0.54) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL3718998 | 0.82 | MAPT (0.52) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL2718370 | 0.82 | SYK (0.53) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL28282980 | 0.80 | MAPK8 (0.52) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL30260224 | 0.80 | MAPK1 (0.51) | MAPTHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1221188 | 0.78 | TP53 (0.48) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL28079567 | 0.77 | RPS6KB1 (0.65) | MAPTHTTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540129-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2026-02-03 | — | — | US | disclosed |
| US-20250270190-A1 | KIT INHIBITORS | BLUEPRINT MEDICINES CORPORATION | 2025-08-28 | — | — | US | disclosed |
| US-20220372018-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2022-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250270190-A1 | KIT INHIBITORS | KIT, ABL1, APC | MAPT 4237/4885HTT 2531/4885KDM4E 302/4885 |
| US-12540129-B2 | KIF18A inhibitors | KIF18A, KIFC1, KIF2C | MAPT 645/4885HTT 3659/4885KDM4E 487/4885 |
| US-20220372018-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | MAPT 315/4885HTT 2800/4885KDM4E 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.