Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1326560 | 0.75 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1LMNATSHRGAA | |
| SCHEMBL1179711 | 0.71 | NR1H4 (0.38) | ALDH1A1L3MBTL1GHSRLMNATSHR | |
| SCHEMBL10268372 | 0.68 | SMN1; SMN2 (0.53) | ALDH1A1L3MBTL1NPC1RAB9ATSHR | |
| SCHEMBL5041655 | 0.67 | NPC1 (0.33) | ALDH1A1L3MBTL1NPC1RAB9ATSHR | |
| SCHEMBL1679666 | 0.66 | LMNA (0.44) | ALDH1A1NPC1LMNAGAAMAPT | |
| SCHEMBL22790395 | 0.66 | TDP1 (0.53) | ALDH1A1L3MBTL1NPC1GHSRLMNA | |
| SCHEMBL3642232 | 0.65 | GHSR (0.49) | ALDH1A1L3MBTL1GHSRLMNATSHR | |
| SCHEMBL12168922 | 0.65 | GHSR (0.49) | ALDH1A1L3MBTL1GHSRLMNATSHR | |
| SCHEMBL10405275 | 0.65 | KMT2A (0.40) | ALDH1A1L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL3638890 | 0.64 | GHSR (0.48) | ALDH1A1L3MBTL1NPC1GHSRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |