Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | UNG | P13051 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3641704 | 0.88 | LOXL2 (0.47) | GAAKDM4E | |
| SCHEMBL3343678 | 0.81 | LOXL2 (0.50) | SLC6A4SLC6A3 | |
| SCHEMBL3343098 | 0.79 | LOXL2 (0.48) | — | |
| SCHEMBL8127899 | 0.76 | LMNA (0.68) | GAAANPEPENPEPSLC6A4SLC6A3 | |
| SCHEMBL1860176 | 0.76 | ANPEP (0.44) | ANPEPENPEPSLC6A4SLC6A3 | |
| SCHEMBL8076505 | 0.73 | HTR1A (0.46) | ANPEPENPEPSLC6A4SLC6A3 | |
| SCHEMBL3641253 | 0.73 | ALDH1A1 (0.41) | ANPEPENPEPKMT2AMEN1 | |
| SCHEMBL3338753 | 0.72 | HTR1A (0.46) | ANPEPENPEPSLC6A4SLC6A3 | |
| SCHEMBL3643578 | 0.72 | CASR (0.42) | GAAKMT2AMEN1 | |
| SCHEMBL14160236 | 0.72 | SCN1A (0.55) | SLC6A4SLC6A3KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170815-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156817-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |