SCHEMBL3639558

SCHEMBL3639558

CCCCOC(=O)OC(=O)[C@@H](N)Cc1c[nH]c2ccc(Br)cc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.48
HTR1B P28222 2/20 0.47
MTNR1A P48039 1/20 0.46
MTNR1B P49286 1/20 0.46
HTR2A P28223 3/20 0.45
HTR1A P08908 3/20 0.45
KMT2A Q03164 2/20 0.45
HTR2C P28335 2/20 0.45
SLC6A4 P31645 2/20 0.45
HTR2B P41595 2/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
CYP3A4 P08684 1/20 0.45
ADORA3 P0DMS8 1/20 0.45
MAPT P10636 1/20 0.45
ALOX15 P16050 1/20 0.45
TSHR P16473 1/20 0.45
NFKB1 P19838 1/20 0.45
HTR7 P34969 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3018303 0.83 MTNR1A (0.47) SCN9AHTR1BMTNR1AMTNR1BHTR2A
SCHEMBL5263791 0.82 SCN9A (0.64) SCN9AHTR1BMTNR1AMTNR1BHTR2A
SCHEMBL3853949 0.82 SCN9A (0.64) SCN9AHTR1BMTNR1AMTNR1BHTR2A
SCHEMBL14116366 0.82 SCN9A (0.64) SCN9AHTR1BMTNR1AMTNR1BHTR2A
SCHEMBL27659895 0.81 MTNR1A (0.54) SCN9AHTR1BMTNR1AMTNR1BHTR2A
SCHEMBL1197489 0.81 MTNR1A (0.54) SCN9AHTR1BMTNR1AMTNR1BHTR2A
SCHEMBL14066849 0.81 MTNR1A (0.54) SCN9AHTR1BMTNR1AMTNR1BHTR2A
SCHEMBL7091653 0.81 KMT2A (0.60) SCN9AHTR1BHTR2AHTR1AKMT2A
Hydrochloric Acid SCHEMBL28558220 0.80 MTNR1A (0.53) SCN9AHTR1BMTNR1AMTNR1BHTR2A
Hydrochloric Acid SCHEMBL28173761 0.80 MTNR1A (0.53) SCN9AHTR1BMTNR1AMTNR1BHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2178537-A1 BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS Merck Sharp & Dohme Corp. (US) 2010-04-28 EP disclosed
WO-2009011836-A1 BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS MERCK & CO., INC. (US) 2009-01-22 WO disclosed