Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27523182 | 0.98 | ALDH1A1 (0.43) | ALDH1A1GAAKMT2AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL8895520 | 0.85 | PTGES (0.49) | — | |
| SCHEMBL13296132 | 0.82 | RAB9A (0.55) | ALDH1A1GAAKMT2AMEN1NPC1 | |
| SCHEMBL364110 | 0.81 | HDAC3 (0.58) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL6933112 | 0.81 | ALDH1A1 (0.57) | ALDH1A1GAAKMT2AMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL4438185 | 0.80 | P4HTM (0.56) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL6651796 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAKMT2AMEN1NPC1 | |
| Dimethylamine SCHEMBL15266781 | 0.78 | HDAC3 (0.54) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL27334382 | 0.77 | ALDH1A1 (0.55) | ALDH1A1GAAKMT2AMEN1NPC1 | |
| SCHEMBL27480275 | 0.77 | ALDH1A1 (0.55) | ALDH1A1GAAKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271327-A1 | PHARMACEUTICAL COMPOSITION COMPRISING RIMEPORIDE FOR TREATING DISEASES ASSOCIATED WITH INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION | Merck Patent GmbH (DE) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009135583-A1 | PHARMACEUTICAL COMPOSITION COMPRISING RIMEPORIDE FOR TREATING DISEASES ASSOCIATED WITH INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION | MERCK PATENT GMBH (DE) | 2009-11-12 | — | — | WO | disclosed |
| CN-1211370-C | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2005-07-20 | — | — | CN | disclosed |
| CN-1326928-A | Biphenyl sulfonyl amino-cyanogen, its preparing method and use as medicine thereof | AVENTIES PHARMACY GMBH (DE) | 2001-12-19 | — | — | CN | disclosed |
| CN-1309645-A | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2001-08-22 | — | — | CN | disclosed |
| US-5968978-A | ANTIARRYTHMIA AGENTS, ANTIISCHEMIC AGENTS, INHIBIT PROLIFERATION OF CELLS | HOECHST MARION ROUSSEL DEUTSCHLAND (DE) | 1999-10-19 | — | — | US | disclosed |
| CN-1212255-A | Biphenylsulfonylcyanamides, method for the production thereof and use thereof as medicaments | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-03-31 | — | — | CN | disclosed |