SCHEMBL364459

SCHEMBL364459

O=[N+]([O-])c1cnc(Cl)c(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
HSD17B10 Q99714 1/20 0.50
LMNA P02545 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
MAPT P10636 2/20 0.47
RECQL P46063 1/20 0.47
AHR P35869 1/20 0.45
KMT2A Q03164 4/20 0.45
GPR35 Q9HC97 1/20 0.44
PDE7A Q13946 3/20 0.43
PDE4B Q07343 1/20 0.42
PDE4D Q08499 1/20 0.42
PDE7B Q9NP56 1/20 0.42
IDO1 P14902 1/20 0.41
MEN1 O00255 2/20 0.41
NPC1 O15118 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 1/20 0.41
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29438693 1.00 ALDH1A1 (0.54) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL10857430 0.82 ALDH1A1 (0.52) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL985995 0.82 AHR (0.51) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL15529688 0.82 ALDH1A1 (0.52) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL29780392 0.82 AHR (0.51) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL1038613 0.80 ALDH1A1 (0.50) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL1303639 0.80 ALDH1A1 (0.50) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL3345475 0.80 ALDH1A1 (0.50) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL1162908 0.80 ALDH1A1 (0.57) ALDH1A1HSD17B10LMNATDP1MAPT
SCHEMBL31143401 0.80 ALDH1A1 (0.47) ALDH1A1LMNATDP1MAPTRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 541 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115433121-B Synthetic method of aliphatic diamine monomer for preparing transparent polyimide 东南大学 2023-11-28 CN claimed
CN-115433121-A Synthetic method of aliphatic diamine monomer for preparing transparent polyimide 东南大学 2022-12-06 CN claimed
CN-112142654-A Aromatic diamine monomer containing fluorene group and pyridine heterocyclic structure and preparation method and application thereof 东华大学 2020-12-29 CN claimed
US-20260125381-A1 NOVEL Kv3 CHANNEL MODULATORS MERCK SHARP & DOHME LLC (US) 2026-05-07 US disclosed
US-20260078127-A1 HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 BOEHRINGER INGELHEIM INT (DE) 2026-03-19 US disclosed
US-20260049085-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME SCHRÖDINGER, INC. (US) 2026-02-19 US disclosed
US-20250276983-A1 COMPOUNDS AND METHODS FOR MODULATING HER2 IAMBIC THERAPEUTICS, INC. 2025-09-04 US disclosed
US-12404260-B2 Pyridine rings containing derivatives as MALT1 inhibitors JANSSEN PHARMACEUTICA NV (BE) 2025-09-02 US disclosed
EP-4604945-A2 NOVEL KV3 CHANNEL MODULATORS Merck Sharp & Dohme LLC (US) 2025-08-27 EP disclosed
US-12398146-B2 Heterobicyclic amides as inhibitors of CD38 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2025-08-26 US disclosed
US-20250241300-A1 AGRICULTURAL COMPOSITIONS FOR IMPROVED CROP PRODUCTIVITY AND ENHANCED PHENOTYPES SPOGEN BIOTECH INC. 2025-07-31 US disclosed
US-4548888-A DIFFUSION TRANSFER EASTMAN KODAK COMPANY (US) 1985-10-22 US disclosed
US-4540578-A Pesticidal phenoxypyridyl benzoyl ureas UNION CARBIDE CORPORATION (US) 1985-09-10 US disclosed
EP-0147105-A2 Photographic products employing novel nondiffusible hydrazone dye-releasing compounds EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-07-03 EP disclosed
EP-0113247-A1 Pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for their preparation UNION CARBIDE CORPORATION (US) 1984-07-11 EP disclosed
US-4441913-A PRE- AND POST-EMERGENCE NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1984-04-10 US disclosed
EP-0029123-B1 PROCESS FOR THE PREPARATION OF SUBSTITUTED ANILINES, AND SUBSTITUTED ANILINES BASF Aktiengesellschaft (DE) 1983-06-08 EP disclosed
EP-0068260-A2 Substituted phenoxypropionates, process for their preparation and their use as herbicides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1983-01-05 EP disclosed
EP-0029123-A1 Process for the preparation of substituted anilines, and substituted anilines BASF Aktiengesellschaft (DE) 1981-05-27 EP disclosed
US-4149872-A N-pyridinyl urea and cyclopropanecarboxamide herbicides SHELL OIL COMPANY (US) 1979-04-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12398146-B2 Heterobicyclic amides as inhibitors of CD38 CD38, PARP12, ENTPD2 ALDH1A1 361/4885HSD17B10 1410/4885LMNA 1943/4885
US-20260078127-A1 HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 CD38, CD22, CD79B ALDH1A1 877/4885HSD17B10 610/4885LMNA 2393/4885
US-20260125381-A1 NOVEL Kv3 CHANNEL MODULATORS KCNN3, KCNA3, KCNQ3 ALDH1A1 3929/4885HSD17B10 3444/4885LMNA 2236/4885
US-12404260-B2 Pyridine rings containing derivatives as MALT1 inhibitors MALT1, SQSTM1, PPP3R1 ALDH1A1 2124/4885HSD17B10 962/4885LMNA 3517/4885
US-20260049085-A1 CYCLIC COMPOUNDS AND METHODS OF USING SAME CCR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, MALT1 ALDH1A1 2214/4885HSD17B10 366/4885LMNA 1006/4885
US-20250276983-A1 COMPOUNDS AND METHODS FOR MODULATING HER2 ERBB2, EGFR, ERBB3 ALDH1A1 2783/4885HSD17B10 3425/4885LMNA 2503/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.