Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3643273 | 0.95 | TAAR1 (0.44) | TAAR1IDO1AGXTSIGMAR1DUT | |
| SCHEMBL333905 | 0.86 | TAAR1 (0.46) | TAAR1IDO1AGXTSIGMAR1MAOB | |
| SCHEMBL9566323 | 0.82 | SIGMAR1 (0.40) | TAAR1IDO1AGXTSIGMAR1MAOB | |
| SCHEMBL7003015 | 0.81 | TAAR1 (0.44) | TAAR1IDO1AGXTMAOB | |
| SCHEMBL11482682 | 0.78 | DUT (0.37) | IDO1DUT | |
| SCHEMBL3168839 | 0.78 | GABRA1 (0.47) | TAAR1 | |
| SCHEMBL21268599 | 0.78 | IDO1 (0.42) | IDO1SIGMAR1DUTHTR2AHTR2C | |
| SCHEMBL21068770 | 0.78 | DUT (0.37) | IDO1DUT | |
| SCHEMBL410888 | 0.77 | DUT (0.40) | TAAR1IDO1SIGMAR1DUTHTR2A | |
| SCHEMBL722684 | 0.77 | IDO1 (0.56) | TAAR1IDO1AGXTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170345-A1 | THERAPEUTIC SUBSTITUTED CYCLOPENTANES FOR REDUCING INTRAOCULAR PRESSURE | Allergan, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009006370-A1 | THERAPEUTIC SUBSTITUTED CYCLOPENTANES FOR REDUCING INTRAOCULAR PRESSURE | ALLERGAN, INC. (US) | 2009-01-08 | — | — | WO | disclosed |