SCHEMBL3645450

SCHEMBL3645450

C[Si](C)(C)C(C(N)=O)C(N)=O

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.35
ALOX15 P16050 1/20 0.35
BLM P54132 1/20 0.35
PMP22 Q01453 1/20 0.35
ALDH1A1 P00352 1/20 0.31
OR51E2 Q9H255 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3645446 0.85 SLC7A5 (0.32) LMNAALOX15BLMPMP22
SCHEMBL222605 0.73 LMNA (0.35) LMNAALOX15BLMPMP22ALDH1A1
SCHEMBL3586576 0.71 LMNA (0.33) LMNAALOX15BLMPMP22
SCHEMBL10583658 0.71
SCHEMBL7098668 0.71
SCHEMBL31415558 0.69 TP53 (0.39) LMNAALOX15ALDH1A1TDP1
SCHEMBL30723428 0.69
Isobutyramide SCHEMBL11109750 0.62 LMNA (0.46) LMNAALOX15BLMPMP22ALDH1A1
SCHEMBL2430704 0.62
SCHEMBL449716 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2170909-A1 PROCESS FOR THE SILYLATION OF BETA-LACTAM COMPOUNDS DSM IP Assets B.V. (NL) 2010-04-07 EP disclosed
WO-2009016170-A1 PROCESS FOR THE SILYLATION OF BETA-LACTAM COMPOUNDS DSM IP ASSETS B.V. (NL) 2009-02-05 WO disclosed
CN-1203096-C Polymerization catalyst for unsaturated monomer, novel transition metal compound, polymerization method using the same, and copolymer MITSUI CHEMICALS INC (JP) 2005-05-25 CN disclosed
CN-1124277-C Preparation method of penicillin and cephalosporin BIOCHEMIE GMBH (AT) 2003-10-15 CN disclosed
CN-1062272-C Silylation process BIOCHEMIE GMBH (AT) 2001-02-21 CN disclosed
CN-1280982-A Preparation method of penicillin and cephalosporin BIOCHEMIE GMBH (AT) 2001-01-24 CN disclosed
CN-1164235-A Silylation process BIOCHEMIE GMBH (AT) 1997-11-05 CN disclosed