Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222605 | 0.97 | LMNA (0.35) | LMNAALOX15BLMPMP22 | |
| SCHEMBL11142184 | 0.80 | — | — | |
| SCHEMBL3645450 | 0.71 | LMNA (0.35) | LMNAALOX15BLMPMP22 | |
| SCHEMBL8312889 | 0.71 | LMNA (0.30) | LMNAALOX15BLMPMP22 | |
| SCHEMBL5435336 | 0.71 | CA1 (0.34) | LMNAALOX15BLMPMP22 | |
| SCHEMBL5477218 | 0.69 | — | — | |
| SCHEMBL4746690 | 0.69 | TDP1 (0.41) | — | |
| SCHEMBL10583658 | 0.69 | — | — | |
| SCHEMBL7098668 | 0.69 | — | — | |
| SCHEMBL5050650 | 0.67 | TP53 (0.39) | LMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668155-B1 | NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-11-26 | — | — | EP | disclosed |
| EP-2668155-A2 | NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-04 | — | — | EP | disclosed |
| US-8592426-B2 | Aryl-benzocycloalkyl amide derivatives | Hoffmann—La Roche Inc. (US) | 2013-11-26 | — | — | US | disclosed |
| US-20130018055-A1 | NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | US | disclosed |
| WO-2012101011-A2 | NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| US-7759372-B2 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |
| EP-2033952-A1 | Nitrogen-containing Heteroaryl compounds having HIV Integrase Inhibitory Activity | Shionogi&Co., Ltd. (JP) | 2009-03-11 | — | — | EP | disclosed |
| EP-1375486-B1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2008-10-15 | — | — | EP | disclosed |
| US-20060293334-A1 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | FUJI MASAHIRO | 2006-12-28 | — | — | US | disclosed |
| US-7148237-B2 | Nitrogen-containing heteroaryl compounds having HIV integrase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2006-12-12 | — | — | US | disclosed |
| EP-1375486-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |
| EP-0759437-B1 | PROCESSES FOR THE PRODUCTION OF 2-ISOCEPHEM DERIVATIVES | OTSUKA KAGAKU KK (JP) | 2003-06-04 | — | — | EP | disclosed |
| US-20020115669-A1 | Oxazolidinone chemotherapeutic agents | ABBOTT LABORATORIES | 2002-08-22 | — | — | US | disclosed |
| EP-1201670-A2 | Process for preparing 2-oxaisocephem derivatives | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 2002-05-02 | — | — | EP | disclosed |
| WO-2002018354-A1 | OXAZOLIDINONES AND THEIR USE AS ANTIBACTERIAL AGENTS | ABBOTT LABORATORIES (US) | 2002-03-07 | — | — | WO | disclosed |
| US-6063918-A | Process for preparing 2-isocephem derivatives | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 2000-05-16 | — | — | US | disclosed |
| US-5688942-A | Process for preparing 2-isocephem derivatives | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1997-11-18 | — | — | US | disclosed |
| EP-0759437-A1 | PROCESSES FOR THE PRODUCTION OF 2-ISOCEPHEM DERIVATIVES | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1997-02-26 | — | — | EP | disclosed |
| US-4614614-A | Process for the manufacture of optically active azetidinones | CIBA-GEIGY CORPORATION (US) | 1986-09-30 | — | — | US | disclosed |
| EP-0126709-A1 | Process for the preparation of optically active azetidinones | CIBA-GEIGY AG (CH) | 1984-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293334-A1 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | ZC3HAV1, INTS9, PRDM9 | LMNA 2941/4885ALOX15 2722/4885BLM 2821/4885 |
| US-20130018055-A1 | NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES | CYP1A1, AHR, CYP1B1 | LMNA 1830/4885ALOX15 4606/4885BLM 678/4885 |
| US-20020115669-A1 | Oxazolidinone chemotherapeutic agents | TOP1, OXA1L, TK1 | LMNA 3931/4885ALOX15 1665/4885BLM 3463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.