Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 4/20 | 0.44 |
| ▸ | CES1 | P23141 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL599311 | 1.00 | TDP1 (0.45) | TDP1L3MBTL1ATMGAAHSP90AA1 | |
| SCHEMBL7220889 | 0.82 | CA1 (0.47) | L3MBTL1ATMGAACES2CES1 | |
| SCHEMBL4363316 | 0.79 | TDP1 (0.48) | TDP1L3MBTL1NPC1RAB9ACES2 | |
| SCHEMBL10353222 | 0.78 | TDP1 (0.47) | TDP1L3MBTL1NPC1RAB9ACES2 | |
| SCHEMBL6652948 | 0.78 | CES2 (0.50) | TDP1L3MBTL1NPC1RAB9ACES2 | |
| SCHEMBL23706328 | 0.76 | TDP1 (0.45) | TDP1L3MBTL1NPC1RAB9ACES2 | |
| SCHEMBL571674 | 0.76 | TDP1 (0.45) | TDP1L3MBTL1NPC1RAB9ACES2 | |
| SCHEMBL4873699 | 0.76 | TDP1 (0.45) | TDP1L3MBTL1GAANPC1RAB9A | |
| SCHEMBL6081855 | 0.76 | PGR (0.46) | TDP1L3MBTL1ATMNPC1RAB9A | |
| SCHEMBL10580248 | 0.76 | TDP1 (0.45) | TDP1L3MBTL1NPC1RAB9ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181108-A2 | 3-HETROCYCLYLIDENE-INDOLINONE DERIVATIVES AS INHIBITORS OF SPECIFIC CELL CYCLE KINASES | Boehringer Ingelheim International GmbH (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2008152014-A2 | 3-HETROCYCLYLIDENE-INDOLINONE DERIVATIVES AS INHIBITORS OF SPECIFIC CELL CYCLE KINASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |