⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12174860 | 0.89 | LMNA (0.43) | — | |
| SCHEMBL12174861 | 0.89 | HTT (0.31) | — | |
| SCHEMBL5317263 | 0.88 | — | — | |
| SCHEMBL1026427 | 0.88 | — | — | |
| SCHEMBL12174875 | 0.87 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL15195760 | 0.87 | ALDH1A1 (0.33) | — | |
| SCHEMBL1584170 | 0.86 | CES2 (0.50) | — | |
| SCHEMBL14488967 | 0.85 | HTT (0.33) | — | |
| SCHEMBL12174874 | 0.83 | — | — | |
| SCHEMBL13779600 | 0.83 | PLG (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106661017-B | Bicyclic or tricyclic heterocyclic compounds | 田边三菱制药株式会社 | 2019-09-24 | — | — | CN | disclosed |
| CN-106661017-A | novel bicyclic or tricyclic heterocyclic compounds | 田边三菱制药株式会社 | 2017-05-10 | — | — | CN | disclosed |
| CN-101481381-B | Method for preparing ciprofloxacin by piperazine reaction | JIUSHENG CHUANGXIN PHARMACEUTICAL TECHNOLOGY DEV CO LTD | 2011-07-20 | — | — | CN | disclosed |
| EP-2170864-A1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | Bristol-Myers Squibb Company (US) | 2010-04-07 | — | — | EP | disclosed |
| CN-101481381-A | Method for preparing ciprofloxacin by piperazine reaction | NINGBO ECONOMIC & TECHNOLOGY D (CN) | 2009-07-15 | — | — | CN | disclosed |
| WO-2009012275-A1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-22 | — | — | WO | disclosed |
| US-4431665-A | Acylated laidlomycin derivatives | SYNTEX (U.S.A.) INC. (US) | 1984-02-14 | — | — | US | disclosed |
| EP-0024189-B1 | ACYLATED LAIDLOMYCIN DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS | SYNTEX (U.S.A.) INC. (US) | 1983-03-02 | — | — | EP | disclosed |
| EP-0024189-A1 | Acylated laidlomycin derivatives, their preparation and compositions | SYNTEX (U.S.A.) INC. (US) | 1981-02-25 | — | — | EP | disclosed |