Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | WNT1 | P04628 | 4/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652871 | 0.88 | LTA4H (0.40) | EGFRBTKDYRK1AAXLCNR2 | |
| SCHEMBL3642834 | 0.86 | PTK2 (0.38) | EGFRGSK3BDYRK1AWNT1PTK2 | |
| SCHEMBL3650207 | 0.84 | GPR6 (0.41) | EGFRBTKPTK2 | |
| SCHEMBL3652561 | 0.82 | EGFR (0.40) | EGFRBTKGSK3BPTK2CNR2 | |
| SCHEMBL3650361 | 0.82 | CSF1R (0.41) | EGFRBTKGSK3BDYRK1AWNT1 | |
| SCHEMBL3650935 | 0.81 | ACHE (0.40) | EGFRBTKPTK2ABL1 | |
| SCHEMBL3650240 | 0.81 | EGFR (0.47) | EGFRBTKGSK3B | |
| SCHEMBL3651887 | 0.81 | PTK2 (0.47) | PTK2 | |
| SCHEMBL27807596 | 0.80 | GRM5 (0.39) | EGFRBTKPTK2MELKCNR2 | |
| SCHEMBL3654033 | 0.80 | EGFR (0.39) | EGFRBTKDYRK1AMELKCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190825-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026276-A1 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-02-26 | — | — | WO | disclosed |