Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3648320 | 0.92 | MEN1 (0.51) | SMN1; SMN2CYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL3650741 | 0.92 | MAPT (0.47) | SMN1; SMN2CYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL3650434 | 0.90 | KMT2A (0.41) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2912844 | 0.87 | LMNA (0.49) | SMN1; SMN2CYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL3651333 | 0.86 | NPC1 (0.42) | SMN1; SMN2RAB9ANPC1POLBALDH1A1 | |
| SCHEMBL3651170 | 0.84 | NPC1 (0.40) | SMN1; SMN2RAB9ANPC1POLBMEN1 | |
| SCHEMBL3648088 | 0.84 | MEN1 (0.48) | SMN1; SMN2CYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL3648565 | 0.84 | MAPT (0.44) | SMN1; SMN2CYP1A2CYP3A4CYP2C19RAB9A | |
| SCHEMBL3645321 | 0.83 | MEN1 (0.50) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL3653797 | 0.81 | RAB9A (0.45) | SMN1; SMN2RAB9ANPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | claimed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | claimed |
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | disclosed |