Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652010 | 1.00 | P2RX7 (0.51) | P2RX7LMNAATMCA2CA5A | |
| SCHEMBL22552853 | 1.00 | P2RX7 (0.51) | P2RX7LMNAATMCA2CA5A | |
| SCHEMBL3957822 | 0.87 | P2RX7 (0.54) | P2RX7LMNACTSK | |
| SCHEMBL7100122 | 0.86 | P2RX7 (0.49) | P2RX7LMNAATMCA2CA1 | |
| SCHEMBL4972042 | 0.86 | P2RX7 (0.54) | P2RX7LMNACA5ACTSK | |
| SCHEMBL6135399 | 0.86 | P2RX7 (0.49) | P2RX7LMNAATMCA2CA1 | |
| SCHEMBL9476901 | 0.86 | CTRB1 (0.56) | P2RX7LMNACA2GAACA1 | |
| SCHEMBL3948746 | 0.86 | P2RX7 (0.54) | P2RX7LMNACA5ACTSK | |
| SCHEMBL7100119 | 0.86 | P2RX7 (0.49) | P2RX7LMNAATMCA2CA1 | |
| SCHEMBL7990303 | 0.85 | P2RX7 (0.47) | P2RX7LMNAATMCA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195288-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009036996-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2009-03-26 | — | — | WO | disclosed |