Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.35 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365005 | 0.93 | CYP11B1 (0.37) | ACHECYP11B1CYP11B2PLA2G10PLA2G1B | |
| SCHEMBL366611 | 0.88 | ACHE (0.38) | ACHECYP11B1CYP11B2PLA2G10PLA2G1B | |
| SCHEMBL366530 | 0.85 | CYP11B1 (0.35) | ACHECYP11B1CYP11B2SCN9A | |
| SCHEMBL366373 | 0.81 | MAPT (0.37) | ACHESIGMAR1 | |
| SCHEMBL365188 | 0.81 | CYP11B1 (0.39) | ACHECYP11B1CYP11B2SCN9A | |
| SCHEMBL365914 | 0.80 | MAPT (0.34) | ACHE | |
| SCHEMBL365924 | 0.80 | ACHE (0.42) | ACHE | |
| SCHEMBL365216 | 0.78 | ACHE (0.36) | ACHECYP11B1CYP11B2PLA2G10PLA2G1B | |
| SCHEMBL366612 | 0.76 | ACHE (0.38) | ACHECYP11B1CYP11B2PLK1PDE4A | |
| SCHEMBL366850 | 0.75 | MAPT (0.37) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |