Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365188 | 0.93 | CYP11B1 (0.39) | LMNAKMT2AALDH1A1LTB4RLTB4R2 | |
| SCHEMBL366373 | 0.92 | MAPT (0.37) | MAPTTP53LMNARXFP1CNR2 | |
| SCHEMBL365168 | 0.92 | ACHE (0.41) | LTB4RLTB4R2 | |
| SCHEMBL365768 | 0.91 | ALOX5 (0.38) | MAPTTP53LMNARXFP1CNR2 | |
| SCHEMBL366750 | 0.90 | PPARG (0.33) | MAPTCNR2MEN1KMT2AALDH1A1 | |
| SCHEMBL366899 | 0.90 | PLA2G4A (0.36) | MAPTTP53LMNARXFP1CNR2 | |
| SCHEMBL366815 | 0.86 | MEN1 (0.45) | MAPTTP53LMNARXFP1CNR2 | |
| SCHEMBL366611 | 0.86 | ACHE (0.38) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL365592 | 0.84 | MRGPRX4 (0.39) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL366564 | 0.84 | ALDH1A1 (0.38) | MAPTTP53LMNARXFP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |