Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366079 | 0.89 | KDM4E (0.42) | CYP11B1CYP11B2ACHEMEN1ALDH1A1 | |
| SCHEMBL365005 | 0.87 | CYP11B1 (0.37) | CYP11B1CYP11B2ACHEMEN1MAPK1 | |
| SCHEMBL365215 | 0.85 | ACHE (0.36) | CYP11B1CYP11B2ACHESCN9A | |
| SCHEMBL366815 | 0.81 | MEN1 (0.45) | MEN1ALDH1A1POLBMAPK1KMT2A | |
| SCHEMBL367690 | 0.80 | MEN1 (0.43) | ACHEMEN1ALDH1A1POLBMAPK1 | |
| SCHEMBL366531 | 0.79 | MEN1 (0.36) | CYP11B1CYP11B2ACHEMEN1ALDH1A1 | |
| SCHEMBL365113 | 0.77 | ALDH1A1 (0.41) | CYP11B1CYP11B2MEN1ALDH1A1POLB | |
| SCHEMBL366080 | 0.76 | ALDH1A1 (0.38) | CYP11B1CYP11B2ACHEMEN1ALDH1A1 | |
| SCHEMBL365188 | 0.75 | CYP11B1 (0.39) | CYP11B1CYP11B2ACHEALDH1A1KMT2A | |
| SCHEMBL366611 | 0.73 | ACHE (0.38) | CYP11B1CYP11B2ACHEMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |