Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254458 | 0.88 | ALDH1A1 (0.41) | MRGPRX4RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL5882318 | 0.83 | ALDH1A1 (0.41) | — | |
| SCHEMBL31371185 | 0.82 | CALM1 (0.50) | SMN1; SMN2TP53HPGDMEN1KMT2A | |
| SCHEMBL25665190 | 0.78 | RXRA (0.46) | PKMRXRACA1CA2KDM4E | |
| SCHEMBL31371244 | 0.78 | MRGPRX4 (0.53) | MRGPRX4RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL31385466 | 0.78 | MRGPRX4 (0.53) | MRGPRX4RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL5341608 | 0.77 | MRGPRX4 (0.52) | MRGPRX4RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL31327317 | 0.77 | CA2 (0.41) | MRGPRX4RAB9ASMN1; SMN2NFKB1HPGD | |
| SCHEMBL23090473 | 0.77 | CA1 (0.44) | MRGPRX4NFKB1NFKB2RELAHPGD | |
| SCHEMBL14788135 | 0.77 | IDO1 (0.38) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197876-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | Glaxosmithkline LLC (US) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009032667-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |