Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.61 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGAV | P06756 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91397 | 0.88 | ROCK2 (0.62) | ROCK2ROCK1MMP3 | |
| SCHEMBL353725 | 0.86 | ROCK1 (0.66) | ROCK2ROCK1 | |
| SCHEMBL7454854 | 0.86 | ROCK2 (0.62) | ROCK2ROCK1 | |
| SCHEMBL5879508 | 0.86 | ROCK2 (0.62) | ROCK2ROCK1MMP3 | |
| SCHEMBL19119361 | 0.85 | ROCK1 (0.47) | ROCK2ROCK1 | |
| SCHEMBL3653728 | 0.85 | ROCK2 (0.59) | ROCK2ROCK1MMP3ITGB3ITGAV | |
| SCHEMBL3653730 | 0.84 | ROCK2 (0.60) | ROCK2ROCK1MMP3 | |
| SCHEMBL2066287 | 0.82 | ROCK1 (0.61) | ROCK2ROCK1 | |
| SCHEMBL353214 | 0.82 | ROCK1 (0.48) | ROCK2ROCK1 | |
| SCHEMBL2068257 | 0.81 | ROCK1 (0.47) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | claimed |
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-2200440-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | Crestone, Inc. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009015208-A1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | REPLIDYNE, INC. (US) | 2009-01-29 | — | — | WO | disclosed |