Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658053 | 0.88 | ALDH1A1 (0.48) | L3MBTL1KDM4EKMT2ATSHRLMNA | |
| SCHEMBL3627423 | 0.88 | PTPN11 (0.46) | L3MBTL1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL3626343 | 0.85 | PTPN11 (0.52) | L3MBTL1KDM4EKMT2ATSHRMEN1 | |
| SCHEMBL3997734 | 0.84 | L3MBTL1 (0.47) | L3MBTL1KDM4ETSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL3231260 | 0.82 | L3MBTL1 (0.46) | L3MBTL1TSHRUSP2LMNAHTT | |
| SCHEMBL3628788 | 0.82 | KMT2A (0.45) | L3MBTL1KDM4EKMT2ATSHRMEN1 | |
| SCHEMBL3624510 | 0.80 | CCR5 (0.42) | L3MBTL1KDM4EKMT2ATSHRMEN1 | |
| SCHEMBL3620263 | 0.78 | GUCY1B2 (0.41) | L3MBTL1KDM4EKMT2ATSHRMEN1 | |
| SCHEMBL16648680 | 0.77 | HRH3 (0.54) | L3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL15578235 | 0.77 | TSHR (0.53) | KDM4EKMT2ATSHRLMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |