Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LGMN | Q99538 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658053 | 0.90 | ALDH1A1 (0.48) | PTPN11ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL3626343 | 0.89 | PTPN11 (0.52) | PTPN11ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL3653995 | 0.88 | L3MBTL1 (0.47) | PTPN11ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL3996895 | 0.83 | MAPT (0.48) | ALDH1A1KDM4EMAPTKMT2APOLB | |
| SCHEMBL3626707 | 0.80 | MEN1 (0.48) | PTPN11ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL3231304 | 0.80 | SMN1; SMN2 (0.52) | ALDH1A1MAPTPOLBTP53NPSR1 | |
| SCHEMBL15578235 | 0.78 | TSHR (0.53) | PTPN11ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL3650017 | 0.78 | DKK1 (0.64) | PTPN11ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL17462447 | 0.78 | GUCY1B2 (0.48) | CDK1 | |
| SCHEMBL21687172 | 0.77 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |