Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1736274 | 0.89 | POLB (0.52) | POLBMAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11247481 | 0.80 | CYP3A4 (0.50) | MAPTALDH1A1SMN1; SMN2TSHRLMNA | |
| SCHEMBL2346437 | 0.80 | GPR35 (0.51) | POLBMAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL14662012 | 0.78 | ALDH1A1 (0.51) | MAPTNPSR1ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL30209222 | 0.78 | SNCA (0.41) | ALDH1A1SMN1; SMN2SNCAKDM4ELMNA | |
| SCHEMBL26458399 | 0.77 | SMN1; SMN2 (0.43) | POLBMAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL11231634 | 0.76 | TSHR (0.54) | POLBMAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29707982 | 0.76 | VCAM1 (0.51) | POLBMAPTALDH1A1MAPK1HPGD | |
| SCHEMBL15880684 | 0.76 | VCAM1 (0.51) | POLBMAPTALDH1A1MAPK1HPGD | |
| SCHEMBL2708859 | 0.76 | ALDH1A1 (0.51) | MAPTNPSR1ALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194982-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | Glaxo Group Limited (GB) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009037294-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-03-26 | — | — | WO | disclosed |