Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651571 | 0.85 | IDO1 (0.35) | NOS2DPP4HTR2AHRH1 | |
| SCHEMBL23095148 | 0.81 | TSHR (0.33) | — | |
| SCHEMBL3657745 | 0.77 | HTR2A (0.42) | HTR2A | |
| SCHEMBL21503429 | 0.76 | RIPK1 (0.34) | DPP4 | |
| SCHEMBL17586080 | 0.75 | RARB (0.32) | — | |
| SCHEMBL14478295 | 0.74 | SLC6A2 (0.46) | HTR2A | |
| SCHEMBL14478251 | 0.74 | SLC6A2 (0.46) | HTR2A | |
| SCHEMBL12450273 | 0.73 | GABRA1 (0.38) | DPP4HTR2A | |
| SCHEMBL19628486 | 0.73 | TAAR1 (0.52) | HTR2AHRH1 | |
| SCHEMBL3655150 | 0.70 | TAAR1 (0.50) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212277-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052350-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |