Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225928 | 1.00 | TAAR1 (0.50) | TAAR1MAOBIDO1ALDH1A1SLC7A5 | |
| SCHEMBL28185303 | 0.85 | ALDH1A1 (0.41) | TAAR1IDO1ALDH1A1FDFT1KCNH2 | |
| SCHEMBL4608415 | 0.85 | ALDH1A1 (0.41) | TAAR1IDO1ALDH1A1FDFT1KCNH2 | |
| SCHEMBL3657745 | 0.83 | HTR2A (0.42) | TAAR1IDO1ALDH1A1HTR2AHTR2C | |
| SCHEMBL28265221 | 0.82 | FFAR2 (0.40) | TAAR1IDO1ALDH1A1KCNH2TMEM97 | |
| SCHEMBL19407026 | 0.81 | ALDH1A1 (0.44) | TAAR1IDO1ALDH1A1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL4685697 | 0.80 | HTR2A (0.63) | TAAR1MAOBIDO1HTR2AHTR2C | |
| SCHEMBL11611907 | 0.79 | ALDH1A1 (0.42) | TAAR1MAOBIDO1ALDH1A1HTR2A | |
| SCHEMBL19628486 | 0.77 | TAAR1 (0.52) | TAAR1ALDH1A1HTR2A | |
| SCHEMBL13003550 | 0.77 | ALDH1A1 (0.46) | TAAR1MAOBIDO1ALDH1A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212277-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052350-A1 | AMINE LINKED MODULATORS OF Y-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |