Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 4/20 | 0.38 |
| ▸ | FNTB | P49356 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.36 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364902 | 0.93 | ALDH1A1 (0.40) | MAPTPOLBLMNAALDH1A1KDM4E | |
| SCHEMBL365359 | 0.88 | ALDH1A1 (0.47) | MAPTPOLBLMNAHTTALDH1A1 | |
| SCHEMBL366275 | 0.87 | ALDH1A1 (0.36) | MAPTNPSR1LMNAHTTALDH1A1 | |
| SCHEMBL365979 | 0.87 | ALDH1A1 (0.36) | MAPTNPSR1LMNAHTTALDH1A1 | |
| SCHEMBL365461 | 0.87 | MAPT (0.33) | MAPTNPSR1POLBALDH1A1KDM4E | |
| SCHEMBL365365 | 0.86 | ALDH1A1 (0.38) | MAPTNPSR1POLBLMNAALDH1A1 | |
| SCHEMBL365753 | 0.86 | ALDH1A1 (0.35) | MAPTNPSR1LMNAHTTALDH1A1 | |
| SCHEMBL366244 | 0.86 | PSEN1 (0.41) | MAPTNPSR1LMNAALDH1A1KDM4E | |
| SCHEMBL366935 | 0.86 | ALDH1A1 (0.39) | MAPTNPSR1POLBLMNAALDH1A1 | |
| SCHEMBL365618 | 0.86 | L3MBTL1 (0.39) | NPC1MAPTNPSR1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |