Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256531 | 0.86 | L3MBTL1 (0.49) | NSD2ABL1PPARGRIN1L3MBTL1 | |
| SCHEMBL6472545 | 0.79 | MAOB (0.50) | NSD2ABL1PPARGRIN1L3MBTL1 | |
| SCHEMBL6471436 | 0.72 | L3MBTL1 (0.46) | RXRARXRBRXRGNSD2ABL1 | |
| SCHEMBL5784957 | 0.72 | MRGPRX4 (0.63) | L3MBTL1MRGPRX4 | |
| SCHEMBL16770891 | 0.72 | SLC6A4 (0.58) | MRGPRX4SLC6A4 | |
| SCHEMBL5201871 | 0.71 | PDE4A (0.44) | POLB | |
| SCHEMBL5907208 | 0.71 | CA12 (0.41) | NSD2ABL1PPARGRIN1L3MBTL1 | |
| SCHEMBL4380372 | 0.70 | MRGPRX4 (0.57) | RXRARXRBRXRGPPARGL3MBTL1 | |
| SCHEMBL2834843 | 0.70 | POLB (0.48) | NSD2ABL1PPARGRIN1L3MBTL1 | |
| SCHEMBL6471478 | 0.70 | HTT (0.45) | RXRANSD2ABL1PPARGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203439-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-Ý1, 4'¨BIPYRIDINYL-2'-ONES | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009033704-A1 | 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-[1, 4'] BIPYRIDINYL-2'-ONES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |