SCHEMBL3655834

SCHEMBL3655834

[O]c1ccccc1OCCCC(Cl)(Cl)Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
HPGD P15428 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HTT P42858 1/20 0.37
L3MBTL1 Q9Y468 7/20 0.37
MAPT P10636 7/20 0.37
NPSR1 Q6W5P4 2/20 0.37
NPC1 O15118 2/20 0.36
POLB P06746 1/20 0.36
PTK2B Q14289 1/20 0.36
KDM4E B2RXH2 1/20 0.35
LMNA P02545 4/20 0.34
JAK2 O60674 1/20 0.34
GAA P10253 1/20 0.34
RAB9A P51151 2/20 0.34
RECQL P46063 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
ATM Q13315 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3658983 0.80 ALDH1A1 (0.42) ALDH1A1HPGDSMN1; SMN2HTTL3MBTL1
SCHEMBL5171646 0.78 KDM4E (0.35) ALDH1A1HPGDSMN1; SMN2HTTL3MBTL1
SCHEMBL11607317 0.76 ALDH1A1 (0.42) ALDH1A1HPGDSMN1; SMN2HTTL3MBTL1
SCHEMBL8765435 0.75 ALDH1A1 (0.41) ALDH1A1HPGDSMN1; SMN2HTTL3MBTL1
SCHEMBL8765729 0.75 KDM4E (0.54) ALDH1A1HPGDSMN1; SMN2HTTL3MBTL1
SCHEMBL49257 0.75 CYP1A2 (0.60) HPGDL3MBTL1MAPTNPSR1LMNA
SCHEMBL7055886 0.74 ALDH1A1 (0.43) ALDH1A1HPGDSMN1; SMN2HTTL3MBTL1
SCHEMBL5481750 0.74 L3MBTL1 (0.34) ALDH1A1HPGDSMN1; SMN2HTTL3MBTL1
SCHEMBL843196 0.73 MAPT (0.56) ALDH1A1L3MBTL1MAPTNPSR1LMNA
SCHEMBL3021327 0.73 PPARA (0.32) SMN1; SMN2L3MBTL1MAPTKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2207773-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF Otsuka Pharmaceutical Co., Ltd. (JP) 2010-07-21 EP disclosed
EP-2089373-A1 STAT3/5 ACTIVATION INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-08-19 EP disclosed
WO-2009057811-A2 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-05-07 WO disclosed
WO-2008044667-A1 STAT3/5 ACTIVATION INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-04-17 WO disclosed
EP-1773797-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-04-18 EP disclosed
WO-2006014012-A2 AROMATIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-02-09 WO disclosed